Nonsense
Nonsense (Medicine)
Nonsense (pronounced: non-sense) is a term used in genetics to describe a mutation in a DNA sequence that results in a premature stop codon, or a 'nonsense codon'. This leads to the creation of a shorter, and often non-functional, protein.
Etymology
The term 'nonsense' originates from the English language, where it is used to describe something that doesn't make sense or has no meaning. In the context of genetics, a 'nonsense' mutation is one that disrupts the normal sequence of genetic code, thus rendering it 'nonsense' or meaningless.
Related Terms
- Mutation: A change in the DNA sequence of a gene.
- Codon: A sequence of three DNA or RNA nucleotides that corresponds with a specific amino acid or stop signal during protein synthesis.
- Protein Synthesis: The process by which the genetic code puts together proteins in the cell.
- Genetic Code: The set of rules by which information encoded in genetic material (DNA or mRNA sequences) is translated into proteins by living cells.
See Also
External links
- Medical encyclopedia article on Nonsense
- Wikipedia's article - Nonsense
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