Selective
Serotonin Reuptake Inhibitors (SSRIs).
Selective Serotonin Reuptake Inhibitors (SSRIs) (pronunciation: sɪˈlɛktɪv sɛrəˈtoʊnɪn riːˈʌptɪk ɪnˈhɪbɪtərs) are a class of drugs used primarily in the treatment of major depressive disorder and anxiety disorders. The etymology of the term comes from their primary function, which is to selectively inhibit the reuptake of serotonin in the brain, thereby increasing the levels of this neurotransmitter available in the synaptic cleft.
Mechanism of Action
SSRIs work by blocking the reuptake of serotonin into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor. This results in more serotonin being available to bind to the receptor sites, which leads to enhanced serotonergic neurotransmission.
Types of SSRIs
There are several types of SSRIs, including fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), and escitalopram (Lexapro).
Side Effects
Common side effects of SSRIs include nausea, upset stomach, diarrhea, and sexual dysfunction. More serious side effects can include an increased risk of suicide, especially in young adults and adolescents.
See Also
- Serotonin and norepinephrine reuptake inhibitors (SNRIs)
- Tricyclic antidepressants (TCAs)
- Monoamine oxidase inhibitors (MAOIs)
References
External links
- Medical encyclopedia article on Selective
- Wikipedia's article - Selective
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