Stiff-person syndrome

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Stiff-person syndrome (pronunciation: /stɪf 'pɜːrs(ə)n 'sɪndrəʊm/), also known as Moersch-Woltman syndrome, is a rare, long-term neurological disorder that features stiffness, functional disability, and functional impairment.

Etymology

The term "Stiff-person syndrome" was first used in 1956 by Frederick Moersch and Henry Woltman at the Mayo Clinic. The syndrome is also known as Moersch-Woltman syndrome in honor of these physicians.

Symptoms

The main symptoms of Stiff-person syndrome include stiffness in the muscles of the trunk and limbs, and functional impairment. The stiffness is often worse in the lower limbs, leading to a characteristic stiff-legged walk. Other symptoms can include spasms, functional disability, and anxiety.

Causes

The exact cause of Stiff-person syndrome is unknown, but it is thought to be an autoimmune disease. This means that the body's immune system mistakenly attacks its own tissues. In the case of Stiff-person syndrome, it is believed that the immune system attacks the nervous system.

Diagnosis

Diagnosis of Stiff-person syndrome is based on the patient's symptoms and medical history, as well as a physical examination. Tests may be done to rule out other conditions that can cause similar symptoms. These tests may include blood tests, MRI scans, and electromyography.

Treatment

Treatment for Stiff-person syndrome is aimed at relieving symptoms and improving function. This may include medications to reduce muscle stiffness and spasms, such as benzodiazepines and baclofen. Physical therapy may also be helpful.

Prognosis

The prognosis for people with Stiff-person syndrome varies. Some people may have mild symptoms and be able to lead relatively normal lives, while others may have severe symptoms that significantly affect their quality of life.

See also

External links

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