5-HT1A receptor

5-HT1A receptor

The 5-HT1A receptor (pronounced as "five H T one A receptor") is a subtype of 5-HT receptor that binds the neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to an inhibitory G protein. Activation of this receptor by serotonin inhibits adenylate cyclase activity and decreases the production of cAMP.

Etymology

The term "5-HT1A" is derived from its role in the serotonin system. "5-HT" stands for "5-hydroxytryptamine", which is the chemical name for serotonin. The "1A" denotes that it is one subtype of the 5-HT1 receptors.

Function

The 5-HT1A receptor is known to be involved in several neurological and biological processes such as anxiety, depression, appetite, sleep, memory, and sexual behavior. It is also implicated in the therapeutic effects of a variety of medications, including certain antidepressants and antipsychotics.

Distribution

The 5-HT1A receptors are widely distributed in the brain, with high concentrations in the raphe nuclei, hippocampus, prefrontal cortex, and amygdala. They are also found in various peripheral tissues, including the cardiovascular system, gastrointestinal tract, and endocrine system.

Related Terms

• 5-HT receptor
• Serotonin
• Neurotransmitter
• G protein-coupled receptor
• Adenylate cyclase
• cAMP
• Anxiety
• Depression
• Appetite
• Sleep
• Memory
• Sexual behavior
• Antidepressants
• Antipsychotics
• Raphe nuclei
• Hippocampus
• Prefrontal cortex
• Amygdala
• Cardiovascular system
• Gastrointestinal tract
• Endocrine system

External links

• Medical encyclopedia article on 5-HT1A receptor
• Wikipedia's article - 5-HT1A receptor

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