ABL (gene)
ABL (gene)
The ABL gene, also known as ABL1 or c-ABL, is a gene found in humans and many other organisms. It is located on chromosome 9 and is involved in cell growth and division.
Pronunciation
The ABL gene is pronounced as "A-B-L gene".
Etymology
The ABL gene is named after the Abelson murine leukemia virus, which was discovered to carry a version of this gene. The term "ABL" is an acronym derived from "Abelson".
Function
The ABL gene provides instructions for making a protein called ABL1. This protein is a type of enzyme called a tyrosine kinase, which plays a role in multiple cellular processes. These include cell division, regulation of cell growth, and response to stress and DNA damage.
Related Terms
- Tyrosine kinase: An enzyme that can transfer a phosphate group from ATP to a protein in a cell.
- Chromosome 9: One of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome.
- Cell division: The process by which a parent cell divides into two or more daughter cells.
- Cell growth: The process by which cells accumulate mass and increase in size.
Disorders associated with ABL (gene)
Mutations in the ABL gene have been associated with certain types of cancer, most notably chronic myeloid leukemia (CML). In CML, a genetic rearrangement occurs between chromosomes 9 and 22, leading to the formation of a fusion gene known as BCR-ABL.
- Chronic myeloid leukemia: A type of cancer that starts in certain blood-forming cells of the bone marrow.
- BCR-ABL: A fusion gene formed as a result of a chromosome rearrangement in chronic myeloid leukemia.
External links
- Medical encyclopedia article on ABL (gene)
- Wikipedia's article - ABL (gene)
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