CGRP

CGRP or Calcitonin Gene-Related Peptide is a neuropeptide that plays a significant role in various physiological and pathological processes.

Pronunciation

CGRP is pronounced as "See-Gee-Ar-Pee".

Etymology

The term CGRP is an acronym derived from the phrase Calcitonin Gene-Related Peptide. It was named so because it is a member of the calcitonin family of peptides and is encoded by the calcitonin gene.

Function

CGRP is primarily involved in the transmission of pain and the dilation of blood vessels. It is found in the central and peripheral nervous system and is released from sensory nerves. CGRP is also involved in the regulation of temperature, food intake, and immune function.

Related Terms

• Calcitonin: A hormone produced by the thyroid gland that lowers blood calcium levels.
• Neuropeptide: Small protein-like molecules used by neurons to communicate with each other.
• Peripheral Nervous System: The part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord.
• Central Nervous System: The part of the nervous system that includes the brain and spinal cord.

Clinical Significance

CGRP has been implicated in a variety of diseases, including migraine, inflammation, and cardiovascular disease. CGRP antagonists are currently being investigated as potential treatments for these conditions.

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