Contracture
{{Expansion depth limit exceeded|Term=Contracture |Short definition=Contract research organization - {{Expansion depth limit exceeded}} (KON-tract REE-serch OR-guh-nih-ZAY-shun) company contracted by another company or research center to undertake certain parts of the conduct of a clinical trial. Company may design, administer and monitor the study and analyze the results. |Type=Contracture - {{Expansion depth limit exceeded}} (kun-TRAK-cher) A permanent tightening of muscles, tendons, skin and surrounding tissues, causing joints to shorten and become very stiff. This prevents normal movement of a joint or other body part. Contractures can be caused by injury, scarring, and nerve damage, or by not using the muscles. It can also occur at some point after a stem cell transplant that has caused chronic graft-versus-host disease {{Expansion depth limit exceeded}} }}