Caryophyllene

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Caryophyllene is a natural bicyclic sesquiterpene that is a constituent of many essential oils, especially clove oil, the oil from the stems and flowers of Syzygium aromaticum (clove), the essential oil of hemp (Cannabis sativa), and the oil of black pepper (Piper nigrum). It is usually found as a mixture with isocaryophyllene and α-humulene, a sesquiterpene isomer.

Chemical Structure and Properties

Caryophyllene has a unique chemical structure that includes a cyclobutane ring, which is rare in nature. Its molecular formula is C₁₅H₂₄, and it has a molecular weight of 204.35 g/mol. The presence of the cyclobutane ring contributes to its distinctive chemical properties and biological activities.

Biological Activity

Caryophyllene is known for its anti-inflammatory, analgesic, and anti-cancer properties. It selectively binds to the CB2 receptor in the endocannabinoid system, which is primarily found in the peripheral nervous system and immune system. This binding action is responsible for its anti-inflammatory and analgesic effects.

Sources

Caryophyllene is found in various plants and their essential oils, including:

• Clove (Syzygium aromaticum)
• Hemp (Cannabis sativa)
• Black pepper (Piper nigrum)
• Hops (Humulus lupulus)
• Basil (Ocimum basilicum)

Uses

Caryophyllene is used in the flavoring and fragrance industries due to its spicy and woody aroma. It is also being studied for its potential therapeutic benefits, particularly in the treatment of inflammation, pain, and certain types of cancer.

Safety and Toxicity

Caryophyllene is generally recognized as safe (GRAS) by the Food and Drug Administration (FDA) when used as a flavoring agent. However, its safety in medicinal applications is still under investigation, and more research is needed to fully understand its potential side effects and interactions with other medications.

See Also

• Sesquiterpene
• Essential oil
• Endocannabinoid system
• Clove oil
• Cannabis sativa
• Piper nigrum

External Links

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