Inguinal lymph nodes

Inguinal lymph nodes are a critical component of the lymphatic system, primarily involved in the immune response and the drainage of lymph fluid from the lower limbs, external genitalia, and the anterior abdominal wall. These nodes are situated in the inguinal region, which is located in the lower portion of the abdomen, just above the leg crease.

Anatomy

The inguinal lymph nodes are divided into two groups: the deep inguinal lymph nodes and the superficial inguinal lymph nodes.

Superficial Inguinal Lymph Nodes

These nodes lie immediately below the skin and are easily palpable in most individuals. They are located along the great saphenous vein, extending from the upper thigh to the groin. The superficial nodes are further categorized into two groups based on their position relative to the femoral vein: the superomedial and superolateral groups.

Deep Inguinal Lymph Nodes

The deep inguinal lymph nodes are situated beneath the fascia of the leg, medial to the femoral vein. They receive lymph from the superficial nodes, the deep areas of the lower limb, and, in some cases, directly from the structures in the pelvic cavity.

Function

The primary function of the inguinal lymph nodes is to filter and drain lymph, which is a clear fluid that circulates through the lymphatic system and carries cells that help fight infections and other diseases. These nodes act as a first line of defense against pathogens that are introduced into the body through the lower extremities, external genitalia, and lower abdominal wall.

Clinical Significance

1. 1. 1. Infections###

Infections in the lower limb, external genitalia, or lower abdomen can lead to the enlargement of the inguinal lymph nodes, a condition known as lymphadenopathy. This can be a sign of local infection, sexually transmitted infections (STIs), or other types of infections.

1. 1. 1. Cancer###

The inguinal lymph nodes can also be sites for metastasis, where cancer cells from other parts of the body spread. For example, melanoma of the lower limbs or cancers of the external genitalia may metastasize to these nodes.

1. 1. 1. Lymphedema###

Blockage or damage to the inguinal lymph nodes can lead to lymphedema, a condition characterized by swelling due to the accumulation of lymph fluid in the tissues.

Diagnosis and Treatment

The evaluation of enlarged inguinal lymph nodes includes a thorough history, physical examination, and possibly imaging studies such as ultrasound or CT scans. Biopsy or fine-needle aspiration may be necessary to diagnose the cause of lymphadenopathy.

Treatment depends on the underlying cause. Infections may require antibiotics, while cancer may necessitate surgery, radiation therapy, or chemotherapy. Lymphedema is managed with compression garments, physical therapy, and in some cases, surgery.

See Also

• Lymphatic system
• Lymphadenopathy
• Lymphedema
• Femoral Vein

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Inguinal_lymph_nodes

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  Illustration of lymphatic chain

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  Gray's anatomy diagram of inguinal lymph nodes

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  Diagram of inguinal lymph nodes

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  Inguinal lymph node in MHCII-GFP mouse

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  Regions of a lymph node