Interstitial nephritis

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Interstitial nephritis
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Synonyms	Tubulointerstitial nephritis
Pronounce	N/A
Specialty	N/A
Symptoms	Fever, rash, eosinophilia, hematuria, pyuria, flank pain
Complications	Chronic kidney disease, acute kidney injury
Onset	Sudden or gradual
Duration	Variable
Types	N/A
Causes	Medications, infections, autoimmune diseases
Risks	Use of certain antibiotics, NSAIDs, proton pump inhibitors
Diagnosis	Urinalysis, blood tests, kidney biopsy
Differential diagnosis	Acute tubular necrosis, glomerulonephritis, pyelonephritis
Prevention	N/A
Treatment	Discontinuation of offending agent, corticosteroids, supportive care
Medication	N/A
Prognosis	Generally good with treatment, but can lead to chronic kidney disease if untreated
Frequency	Rare
Deaths	N/A

Interstitial Nephritis, also known as tubulointerstitial nephritis, is a renal condition characterized by inflammation of the renal interstitium. The renal interstitium is a key component of kidney tissue, surrounding the renal tubules.

Renal Interstitium Anatomy

Microscopic structure of the kidney, highlighting the renal interstitium.

The renal interstitium comprises a collection of cells, extracellular matrix, and fluid, providing structural support to the renal tubules. It plays a crucial role in fluid and electrolyte exchange, as well as the endocrine functions of the kidney.

Causes and Types

Interstitial nephritis can be acute or chronic and is caused by a variety of factors, including:

• Allergic reactions to medications (e.g., antibiotics, NSAIDs)
• Infections
• Autoimmune disorders
• Toxins

Pathophysiology

The condition involves inflammation that leads to damage or destruction of the tubules and interstitial tissue. This can disrupt normal kidney function and lead to renal failure if not properly managed.

Symptoms

Symptoms of interstitial nephritis may include:

• Kidney pain or tenderness
• Changes in urine output
• Fever
• Rash
• Fatigue

Diagnosis

Diagnosis typically involves:

• Laboratory tests (urinalysis, blood tests)
• Imaging studies (ultrasound, CT scan)
• Renal biopsy for definitive diagnosis

Treatment

Treatment depends on the underlying cause and may include:

• Cessation of offending drugs
• Corticosteroids or other immunosuppressive drugs
• Treatment of underlying infections or autoimmune diseases
• Dialysis in cases of severe renal impairment

Prognosis

The prognosis varies based on the cause and severity. Acute interstitial nephritis may be reversible with timely treatment, while chronic forms can lead to permanent kidney damage.

Epidemiology

Interstitial nephritis accounts for a significant portion of acute kidney injuries, with varying prevalence depending on the population and underlying causes.

See Also

• Acute kidney injury
• Chronic kidney disease
• Nephrology
• Renal pathology

External Links

• National Kidney Foundation - Interstitial Nephritis
• Mayo Clinic - Interstitial Nephritis

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