Modified-release dosage

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(Redirected from Extended-release)

Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).

Mechanism of action

Modified-release dosage systems have a number of advantages over traditional dosage forms. They can reduce the frequency of dosing, improve patient compliance, and maintain steady drug plasma levels. This is achieved by controlling the rate, time, and place of release of drugs in the body.

Types of modified-release dosage

There are several types of modified-release dosage, including delayed-release dosage, extended-release dosage, and targeted-release dosage.

  • Delayed-release dosage involves delaying the release of the medication until it has passed through the stomach to avoid the drug being destroyed or inactivated by stomach acids.
  • Extended-release dosage involves the drug being released over an extended period, allowing for a reduction in frequency of dosing.
  • Targeted-release dosage involves the drug being released at a specific target in the body, improving the efficacy of the drug and reducing side effects.

Applications

Modified-release dosage forms are used in a number of therapeutic areas, including the treatment of chronic conditions such as diabetes, hypertension, and neurological disorders. They are also used in the treatment of pain, where sustained release of medication can provide better pain control.

Challenges

Despite the advantages, there are also challenges associated with the use of modified-release dosage forms. These include the complexity of drug formulation, the need for patient education to ensure correct use, and the potential for variable bioavailability.

See also

References


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Contributors: Prab R. Tumpati, MD