Cancer cells undergo EMT to enter the bloodstream where they are able to recruit platelets to use as a physical barrier that helps protect the metastatic cancer cell from elimination by immune cells. The metastatic cancer cell can then use the attached platelets to adhere to P-selectin expressed by activated endothelial cells lining the blood vessel walls. After adhesion, the metastatic cancer cell exits the bloodstream at the secondary site to begin formation of a new tumor. Cs109809 (talk) 19:23, 29 November 2017 (UTC)

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