Glucagon-like peptide-1

Glucagon-like Peptide-1 (GLP-1)

Principals funcions GLP-1

Glucagon-like peptide-1 (GLP-1) is a hormone that is secreted from the intestines in response to food intake. It plays a crucial role in the regulation of blood glucose levels and has been implicated in the pathophysiology of type 2 diabetes.

Glucagon-like Peptide-1 (GLP-1) is an incretin hormone that plays a critical role in glucose metabolism, insulin secretion, and appetite regulation. Produced in the intestinal L cells and certain neurons within the brain, GLP-1 is a key player in the enteroinsular axis, mediating the increase in insulin secretion in response to nutrient intake. This article delves into the physiological functions of GLP-1, its therapeutic applications, particularly in the treatment of type 2 diabetes mellitus and obesity, and highlights recent research in the field.

Physiological Role

GLP-1 exerts multiple actions on glucose homeostasis and gastrointestinal function:

• Insulin Secretion: Enhances insulin secretion from pancreatic β-cells in a glucose-dependent manner, preventing hyperglycemic spikes post-meal.
• Gastric Emptying: Slows gastric emptying, aiding in the reduction of postprandial glucose levels.
• Appetite Regulation: Acts on the brain to promote satiety and reduce food intake, contributing to weight management.
• Glucagon Suppression: Inhibits glucagon secretion, thereby reducing hepatic glucose production.

Illustration of insulin and glucagon regulation in glucose metabolism.

Therapeutic Uses

GLP-1's role in enhancing insulin secretion and promoting satiety has led to the development of GLP-1 receptor agonists for managing type 2 diabetes and obesity:

• Type 2 Diabetes Mellitus: GLP-1 receptor agonists, such as exenatide and liraglutide, improve glycemic control by enhancing insulin secretion and suppressing glucagon release.
• Obesity: These agents reduce appetite and food intake, leading to significant weight loss in patients with obesity.

GLP-1 Receptor Agonists

GLP-1 receptor agonists mimic the action of endogenous GLP-1, offering several benefits:

• Improved glycemic control with a low risk of hypoglycemia
• Weight reduction
• Potential cardiovascular benefits

Function

GLP-1 is secreted by L cells in the intestine in response to food intake. It acts on the pancreas to stimulate insulin secretion and inhibit glucagon secretion, thereby helping to regulate blood glucose levels. GLP-1 also slows gastric emptying and promotes satiety, which can help to control body weight.

Role in disease

Impaired GLP-1 secretion and action have been implicated in the pathophysiology of type 2 diabetes. GLP-1-based therapies, such as GLP-1 receptor agonists and DPP-4 inhibitors, are currently used in the treatment of this disease.

Therapeutic use

GLP-1-based therapies are used in the treatment of type 2 diabetes. These include GLP-1 receptor agonists, which mimic the action of GLP-1, and DPP-4 inhibitors, which prevent the breakdown of GLP-1. These therapies can help to improve blood glucose control and promote weight loss.

See also

• Insulin
• Glucagon
• Type 2 diabetes
• GLP-1 receptor agonists
• DPP-4 inhibitors

References

This article is a medical stub. You can help WikiMD by expanding it!
Most recent articles Ongoing trials	Wikipedia

Tired of Being Overweight?

Achieve lasting results with W8MD's proven weight loss program, trusted by thousands since 2011. Our comprehensive approach tackles weight gain factors like insulin resistance to help you lose weight and keep it off.

Tailored Weight Loss Solutions

W8MD offers personalized weight loss plans, including FDA-approved medications and GLP-1 injections, such as:

• Wegovy
• Zepbound
• Zepbound/Mounjaro
• Liraglutide (brand names: Saxenda/Victoza)

Other options include:

• Phentermine
• Contrave
• Phentermine/topiramate
• Semaglutide
• Tirzepatide

We also offer nutritious, low-glycemic foods and meal replacements to keep you on track.

Convenient Locations

W8MD provides weight loss services in Brooklyn, New York and Greater Philadelphia, with tailored plans and GLP-1 weight loss injections.

Looking for a weight loss clinic in Brooklyn or weight loss doctors in NYC? W8MD's expert team is here to help.

Weight Loss Doctor in NYC

Trust W8MD's best weight loss doctors in NYC for personalized solutions, including wiki Physician Weight Loss Program and GLP-1 injections.

W8MD Weight Loss Clinic in Philadelphia

W8MD in Philadelphia offers FDA-approved medications and weight loss injections. Visit our medical weight loss clinic for expert care.

Find the best weight loss tips in Philadelphia with W8MD.

Take the First Step

Book your consultation today and start your journey:

• Visit W8MD Official Site
• Check out Yelp reviews
• Schedule via Patient Fusion

Call now for medical weight loss:

• NYC: 718-946-5500
• Philadelphia: 215-676-2334

Explore W8MD's NYC Physician Weight Loss Program now!

• Individual results may vary!