Leucovorin

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Leucovorin

Leucovorin (pronounced: loo-koh-VOHR-in), also known as folinic acid, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer, may be used to treat folate deficiency that results from taking folic acid antagonists, and can be used in a treatment regimen for methanol and ethylene glycol poisoning.

Etymology

The term "leucovorin" is derived from leuco-, a combining form meaning "white" in Greek, and -vorin, a suffix used in pharmacological nomenclature.

Usage

Leucovorin is used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of colorectal cancer. It is also used as an antidote to the toxic effects of methotrexate in high-dose therapy, and to treat folate deficiency caused by folic acid antagonists. In addition, it is used in the treatment of methanol and ethylene glycol poisoning.

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