Leuprolide
Leuprolide
Leuprolide (pronounced: loo-PRO-lide) is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH or LHRH). The drug works by stopping the production of certain hormones in the body.
Etymology
The term "Leuprolide" is derived from the chemical structure of the drug, which is a leucine (Leu) derivative of the naturally occurring hormone, proline (Pro), and an amide.
Usage
Leuprolide is used in the treatment of prostate cancer, uterine fibroids, endometriosis, and central precocious puberty. It is also used in assisted reproduction.
Mechanism of Action
Leuprolide acts as an agonist at pituitary GnRH receptors. By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins, thus decreasing levels of testosterone in men and estrogen in women.
Side Effects
Common side effects of leuprolide include hot flashes, mood changes, reduced sexual desire, and erectile dysfunction in men. In women, it can cause menopause-like symptoms, including hot flashes, mood changes, and vaginal dryness.
Related Terms
- Gonadotropin-releasing hormone
- Prostate cancer
- Uterine fibroids
- Endometriosis
- Central precocious puberty
- Testosterone
- Estrogen
External links
- Medical encyclopedia article on Leuprolide
- Wikipedia's article - Leuprolide
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