Spinosad

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An insecticide derived from natural sources



Overview

Chemical structure of Spinosyn A

Spinosad is a natural insecticide derived from the fermentation of a soil bacterium, Saccharopolyspora spinosa. It is used to control a variety of insect pests in agriculture, horticulture, and veterinary medicine. Spinosad is particularly effective against Lepidoptera, Diptera, Thysanoptera, Coleoptera, and some Hymenoptera.

Chemical Composition

Spinosad is composed of two major components, Spinosyn A and Spinosyn D, which are macrolide compounds. The chemical structure of Spinosyn A is shown in the image to the right. These compounds act on the nervous system of insects, causing paralysis and death.

Mode of Action

Spinosad works by activating nicotinic acetylcholine receptors in the insect nervous system, leading to continuous nervous impulses, muscle contractions, and eventual paralysis. This mode of action is unique and provides an alternative to traditional insecticides, reducing the risk of insecticide resistance.

Applications

Spinosad is used in various settings:

  • Agriculture: It is applied to crops to control pests such as caterpillars, fruit flies, and leafminers.
  • Horticulture: Used in gardens and greenhouses to protect ornamental plants.
  • Veterinary medicine: Formulated into products for controlling fleas on pets.

Environmental Impact

Spinosad is considered environmentally friendly due to its low toxicity to mammals, birds, and most beneficial insects. It degrades rapidly in the environment, reducing the risk of long-term contamination.

Safety and Regulations

Spinosad is approved for use in organic farming by several regulatory bodies, including the United States Department of Agriculture (USDA). It is important to follow label instructions to minimize any potential risks to non-target organisms.

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Contributors: Prab R. Tumpati, MD