Frontonasal dysplasia

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Frontonasal dysplasia
Synonyms	Median cleft face syndrome, frontonasal malformation
Pronounce	N/A
Specialty	N/A
Symptoms	Hypertelorism, broad nasal bridge, cleft lip, cleft palate, craniofacial anomalies
Complications	Developmental delay, intellectual disability, vision problems
Onset	Congenital
Duration	Lifelong
Types	N/A
Causes	Genetic mutation
Risks	Family history of the condition
Diagnosis	Clinical examination, genetic testing
Differential diagnosis	Oculoauriculofrontonasal syndrome, craniofrontonasal dysplasia
Prevention	N/A
Treatment	Surgical intervention, speech therapy, occupational therapy
Medication	N/A
Prognosis	Varies depending on severity
Frequency	Rare
Deaths	N/A

Frontonasal dysplasia (FND), also known as Median cleft face syndrome, is a rare genetic disorder that affects the development of the head and face before birth. The condition is characterized by abnormalities that can affect the nose, eyes, and upper lip.

Symptoms and Signs

The most common features of frontonasal dysplasia are widely spaced eyes (hypertelorism), a broad nose, a slit (cleft) in one or both nostrils (bifid nose), and a cleft lip and palate. Other features can include a widow's peak hairline, a flat or absent nasal bridge, and skin-covered gaps in the bones of the forehead (anterior cranial fossa meningocele).

Causes

Frontonasal dysplasia is caused by mutations in the ALX3, ALX4, and ZSWIM6 genes. These genes provide instructions for making proteins that are involved in the development of tissues and organs before birth. Mutations in these genes disrupt the normal development of the head and face, leading to the features of frontonasal dysplasia.

Diagnosis

Diagnosis of frontonasal dysplasia is based on a clinical examination and confirmed by genetic testing. Imaging tests such as X-rays, CT scans, and MRI can also be used to assess the severity of the condition.

Treatment

Treatment for frontonasal dysplasia is symptomatic and supportive. It often involves surgery to correct the facial abnormalities. Other treatments may include speech therapy for those with a cleft palate and special education services for those with learning disabilities.

Prognosis

The prognosis for individuals with frontonasal dysplasia varies. Some individuals have normal intelligence and lead normal lives, while others may have learning disabilities and require special education services.

Gallery

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  Frontonasal dysplasia

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  Tessier classification of craniofacial clefts

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  Diagram of the human skull

See also

• Craniofacial abnormalities
• Genetic disorders
• Cleft lip and palate

References

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