Origin of replication

From WikiMD's medical encyclopedia

(Redirected from Ori (genetics))

Origin of Replication

The Origin of replication (also called replication origin or ORI) is a particular sequence in a genome where DNA replication begins. This can either involve the duplication of an entire chromosome or a small DNA molecule.

Overview

In molecular biology, the origin of replication is the DNA sequence that functions as a starting point for DNA replication. In bacteria, this is typically a single point, whereas in eukaryotes, there are multiple replication origins on the DNA molecule. The specific structure of the origin of replication varies somewhat from species to species, but all share some common characteristics.

Function

The origin of replication is crucial for DNA replication because it provides a point of entry for the enzymes that carry out this process. These enzymes, known as DNA polymerases, cannot initiate the synthesis of a new DNA strand on their own. Instead, they require a primer to which they can add nucleotides. The origin of replication provides this primer.

Structure

The structure of the origin of replication is a specific sequence of nucleotides. This sequence is recognized by certain proteins that bind to the DNA and initiate replication. In bacteria, the origin of replication is a single sequence of about 245 base pairs, known as the DnaA box. In eukaryotes, the origin of replication is more complex and can involve multiple sequences of DNA.

Replication Process

The process of DNA replication begins when the proteins that recognize the origin of replication bind to the DNA. This binding causes the DNA to unwind, creating a replication fork. DNA polymerases then add nucleotides to the primer, synthesizing a new DNA strand.

See also

References


WHO Rod.svg
This article is a medical stub. You can help WikiMD by expanding it!
PubMed
Wikipedia

  • Origin of replication

  • Origin of replication

  • Origin of replication

  • Origin of replication

  • Origin of replication

  • Origin of replication

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP-1 injections from $125.

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:

NYC weight loss doctor appointments

Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.

Linkedin_Shiny_Icon Facebook_Shiny_Icon YouTube_icon_(2011-2013) Google plus


Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Retrieved from "https://wikimd.org/w/index.php?title=Origin_of_replication&oldid=6321654"

Contributors: Prab R. Tumpati, MD