Glutarimide

Glutarimide is a type of chemical compound that belongs to the class of organic compounds known as imidazolidines. Glutarimides are derived from glutaric acid and have a five-membered ring structure. They are used in the synthesis of various pharmaceuticals and biologically active compounds.

Structure and Properties

Glutarimide has a five-membered ring structure with two nitrogen atoms and three carbon atoms. The molecular formula of glutarimide is C5H7NO2. It is a white crystalline solid at room temperature and is soluble in water, alcohol, and ether.

Synthesis

Glutarimide can be synthesized from glutaric acid by dehydration in the presence of phosphorus pentoxide. The reaction proceeds via cyclization to form the five-membered ring structure.

Uses

Glutarimide is used as a building block in the synthesis of various pharmaceuticals and biologically active compounds. For example, it is used in the synthesis of thalidomide, a drug used to treat multiple myeloma and erythema nodosum leprosum.

Safety

As with all chemicals, proper safety precautions should be taken when handling glutarimide. It can cause irritation to the skin, eyes, and respiratory system if not handled properly.

See Also

• Imidazolidine
• Glutaric acid
• Thalidomide

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  Glutarimide structure

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  Lenalidomide substructures