Ringer's lactate solution

 Ringer's lactate solution (RLS), also known as Lactated Ringer's solution, is a balanced crystalloid fluid that is widely used in medical settings for fluid resuscitation in patients suffering from a variety of conditions, including trauma, burns, surgery, and severe dehydration.

Ringer-Lactat-Infusion

Composition

• RLS closely mimics the electrolyte composition of blood plasma, containing the following:
• Sodium (Na+): 130 mEq/L
• Potassium (K+): 4 mEq/L
• Calcium (Ca2+): 3 mEq/L
• Chloride (Cl−): 109 mEq/L
• Lactate: 28 mEq/L
• The lactate component is metabolized in the liver to bicarbonate, thereby helping to buffer metabolic acidosis, a condition often seen in critically ill or injured patients.

Indications

• RLS is a first-line fluid for volume resuscitation in many situations:
• Trauma: RLS is often used in the initial management of patients with significant injuries.
• Surgery: It is commonly used during surgical procedures to replace lost fluids.
• Burns: RLS is the preferred resuscitation fluid in the early management of severe burns.
• Severe Dehydration: This includes conditions such as diarrhea, vomiting, or septic shock where a rapid infusion of fluids may be necessary.

Contraindications

• While RLS is widely used, it is contraindicated in certain scenarios:
• Hyperkalemia: As RLS contains potassium, it should not be used in patients with high potassium levels.
• Lactic acidosis: Given the lactate component, it should be avoided in patients with lactic acidosis as they may not be able to metabolize lactate effectively.
• Severe liver disease: The liver is responsible for metabolizing lactate to bicarbonate, so RLS is usually avoided in patients with severe liver disease.

Administration

RLS is usually administered intravenously. The rate of administration depends on the patient's condition, the severity of fluid loss, and the presence of any contraindications.

See Also

• Intravenous therapy
• Fluid resuscitation
• Dehydration

References

• Thomas, D. R. (2008). Intravenous fluid resuscitation: was Poiseuille right?. Emergency medicine journal, 25(3), 174-180.
• Jhang, W. K., & Kang, H. C. (2014). Cerebral edema after Lactated Ringer's solution therapy in pediatric diabetic ketoacidosis. Korean journal of pediatrics, 57(6), 273-277.

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