5-FU is a drug used to treat cancers of the breast, colon, rectum, stomach, and pancreas. It is used under the brand names Carac, Tolak, Efudex, and Fluoroplex as a cream to treat actinic keratosis (a skin condition that may become cancer). It is also used under the brand name Efudex as a cream to treat basal cell skin cancer that is superficial (not invasive) and cannot be treated with other therapy. 5-FU is being studied in the treatment of other conditions and types of cancer. It stops cells from making DNA and may kill cancer cells. 5-FU is a type of antimetabolite. Also called 5-fluorouracil and 5-fluorouracil.