APTT
APTT
The Activated Partial Thromboplastin Time (APTT) is a medical test that is primarily used to measure the efficiency of both the intrinsic and the common coagulation pathways. Apart from diagnosing hemophilia, the APTT test is also used to monitor the treatment effects with heparin, a commonly used medication in the treatment of blood clotting disorders.
Overview
The APTT test is performed on a sample of a patient's blood to measure the time it takes for a clot to form. The test is often used in conjunction with the Prothrombin Time (PT) test to diagnose the cause of unexplained bleeding or bruising.
Procedure
The APTT test involves adding a substance known as a reagent to a sample of the patient's blood. The reagent triggers the coagulation process and the time it takes for a clot to form is then measured. The normal range for APTT is typically between 30 and 40 seconds, although this can vary depending on the laboratory that analyzes the sample.
Clinical Significance
An extended APTT can indicate a deficiency in any of the following coagulation factors: Factor VIII, Factor IX, Factor XI, and Factor XII. It can also be a sign of the presence of an inhibitor, such as Lupus Anticoagulant, that is interfering with the clotting process. A shorter than normal APTT can indicate a risk of thrombosis or excessive clotting.
See Also
External links
- Medical encyclopedia article on APTT
- Wikipedia's article - APTT
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