Amantadine

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Information about Amantadine

Peramivir is an inhibitor of the influenza neuraminidase enzyme and is used as therapy of acute symptomatic influenza A and B. Peramivir has not been associated with serum enzyme elevations during therapy or with clinically apparent liver injury.

Mechanism of action of Amantadine

Peramivir (per am' i vir) is a sialic acid analog and potent inhibitor of the virus-encoded neuraminidases of influenza A and B. In several prospective clinical trials, peramivir given as a single intravenous infusion [300 to 600 mg] within 2 days of symptomatic onset, shortened the period of symptoms and viral shedding. Peramivir was approved in the United States under an emergency use authorization during the influenza A (H1N1) epidemic in 2009. Peramivir received standard full approval in 2014. Current formal indications are for the treatment of acute, uncomplicated influenza A or B in adults within 2 days of symptom onset. It is not approved for, but is widely used in, patients with complicated, life-threatening influenza. Peramivir is used only for treatment of influenza and is not indicated for prophylaxis after a known exposure. Peramivir is available in single use vials of 200 mg in 20 mL [10 mg/mL] under the brand name Rapivab.

Dosage and administration for Amantadine

The recommended dose is a single intravenous infusion of 600 mg administered over 15 minutes. Side effects from peramivir infusions are uncommon and generally mild, including headache, nausea and vomiting. Rare, but potentially severe adverse events include anaphylaxis and Stevens Johnson syndrome. Recommendations for treatment and prophylaxis of influenza in the United States change frequently in response to changes in the circulating influenza strains and antiviral resistance patterns. Drugs for HIV Infection, in the Subclass Antiretroviral Agents

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