Anti-histone antibodies
Anti-histone antibodies (pronunciation: an-tee-his-tone an-ti-bod-ies) are a type of autoantibody that targets histone proteins, which are integral components of the cell nucleus. They are often present in individuals with autoimmune diseases, particularly systemic lupus erythematosus (SLE).
Etymology
The term "anti-histone antibodies" is derived from the Greek words "anti" (against), "histos" (tissue), and "antibodies" (proteins that the immune system uses to neutralize pathogens such as bacteria and viruses).
Function
Anti-histone antibodies are produced by the immune system when it mistakenly identifies histone proteins as foreign substances. This can lead to inflammation and damage to various tissues and organs in the body.
Clinical significance
Anti-histone antibodies are most commonly associated with drug-induced lupus erythematosus (DILE), a variant of SLE that is triggered by certain medications. They can also be found in other autoimmune conditions such as rheumatoid arthritis and Sjögren's syndrome. Testing for these antibodies can aid in the diagnosis of these conditions.
Related terms
- Autoantibody
- Histone
- Systemic lupus erythematosus
- Drug-induced lupus erythematosus
- Rheumatoid arthritis
- Sjögren's syndrome
External links
- Medical encyclopedia article on Anti-histone antibodies
- Wikipedia's article - Anti-histone antibodies
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