Anti-transglutaminase antibodies

Anti-transglutaminase antibodies (pronunciation: an-tee-trans-gloo-ta-min-ase an-ti-bod-ies) are a type of antibody that the immune system produces in response to an enzyme called transglutaminase.

Etymology

The term "anti-transglutaminase antibodies" is derived from the Greek words "anti" meaning against, "trans" meaning across, "glutamine" a type of amino acid, and "ase" a suffix used in biochemistry to form names of enzymes.

Overview

Anti-transglutaminase antibodies are primarily associated with celiac disease, an autoimmune disorder where the ingestion of gluten leads to damage in the small intestine. The presence of these antibodies is often used as a marker for the diagnosis of celiac disease.

Types

There are two types of anti-transglutaminase antibodies: IgA anti-tTG and IgG anti-tTG. The IgA anti-tTG is the most commonly used test for celiac disease. However, in cases where patients have selective IgA deficiency, the IgG anti-tTG test is used.

Related Terms

• Celiac Disease
• Gluten
• Antibody
• Transglutaminase
• IgA
• IgG

See Also

• Anti-gliadin antibodies
• Anti-endomysial antibodies

External links

• Medical encyclopedia article on Anti-transglutaminase antibodies
• Wikipedia's article - Anti-transglutaminase antibodies

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