Atosiban
Atosiban
Atosiban (/əˈtoʊsɪbæn/) is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist used to halt premature labor.
Etymology
The name "Atosiban" is derived from its chemical structure, which is an analogue of the hormone oxytocin, with modifications to make it act as an antagonist.
Usage
Atosiban is primarily used in pregnant women to halt premature labor by inhibiting the actions of oxytocin and vasopressin on the uterus. It is administered intravenously and has a rapid onset of action.
Mechanism of Action
Atosiban acts as a competitive inhibitor at the oxytocin receptor, thus inhibiting the action of oxytocin on the uterus. It also has some inhibitory action at the vasopressin receptors, which also play a role in uterine contraction.
Side Effects
Common side effects of Atosiban include nausea, vomiting, and headache. More serious side effects may include allergic reactions and changes in heart rate.
Related Terms
- Oxytocin: A hormone that causes increased contraction of the uterus during labor and stimulates the release of milk.
- Vasopressin: A hormone that increases water reabsorption in the kidneys and constricts blood vessels.
- Premature labor: A condition in which labor begins before the 37th week of pregnancy.
See Also
- Tocolytic: A type of medication used to suppress premature labor.
- Antagonist: A substance that interferes with or inhibits the physiological action of another.
External links
- Medical encyclopedia article on Atosiban
- Wikipedia's article - Atosiban
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