Bielschowsky stain
Bielschowsky stain
Bielschowsky stain (pronunciation: bee-el-SHOW-skee) is a silver-based histological stain used primarily in neuropathology. The technique is named after its developer, Max Bielschowsky, a German neurologist and neuropathologist.
Etymology
The term "Bielschowsky stain" is derived from the name of its developer, Max Bielschowsky. Bielschowsky was a prominent figure in the field of neuropathology, contributing significantly to the understanding of neurodegenerative diseases.
Usage
Bielschowsky stain is used to visualize neurofibrillary tangles and senile plaques, which are characteristic features of Alzheimer's disease. The stain works by binding to the neurofibrils in these structures, allowing them to be seen under a microscope.
Procedure
The procedure for Bielschowsky stain involves several steps. First, the tissue sample is fixed and dehydrated. Then, it is treated with a silver solution, which binds to the neurofibrils. The sample is then developed, which turns the silver black and makes the neurofibrils visible. Finally, the sample is cleared and mounted for viewing.
Related Terms
- Max Bielschowsky: The neuropathologist who developed the Bielschowsky stain technique.
- Neuropathology: The study of disease of nervous system tissue.
- Neurofibrillary tangles: Abnormal aggregates of protein that build up inside nerve cells in the brain, characteristic of Alzheimer's disease.
- Senile plaques: Deposits of a protein fragment called beta-amyloid that build up in the spaces between nerve cells, characteristic of Alzheimer's disease.
- Alzheimer's disease: A progressive disease that destroys memory and other important mental functions.
External links
- Medical encyclopedia article on Bielschowsky stain
- Wikipedia's article - Bielschowsky stain
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