Bosentan

Bosentan

Bosentan (pronounced boh-SEN-tan) is a dual endothelin receptor antagonist used in the treatment of pulmonary artery hypertension (PAH). It is marketed under the brand name Tracleer.

Etymology

The name "Bosentan" is derived from the chemical name for the drug, which is [4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl)benzenesulfonamide].

Medical Uses

Bosentan is primarily used to treat pulmonary artery hypertension. It works by blocking the action of endothelin, a natural substance that tightens the blood vessels in the lungs. By blocking the action of endothelin, bosentan helps to decrease blood pressure in the lungs.

Side Effects

Common side effects of bosentan include headache, flushing, low blood pressure, and liver function abnormalities. Serious side effects may include liver failure and birth defects if taken during pregnancy.

Related Terms

• Endothelin receptor antagonist
• Pulmonary artery hypertension
• Endothelin
• Liver function tests

See Also

• List of drugs used for Pulmonary artery hypertension

External links

• Medical encyclopedia article on Bosentan
• Wikipedia's article - Bosentan

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