Bryostatin
Bryostatin
Bryostatin (/braɪˈɒstətɪn/) is a complex macrolide that has been extensively studied for its unique bioactive properties. It is a type of polyketide that is produced by the marine bryozoan, Bugula neritina.
Etymology
The term "Bryostatin" is derived from the name of the marine bryozoan, Bugula neritina, from which it was first isolated, and the Greek word "statos", meaning standing or stopping. The name reflects the compound's ability to inhibit cell proliferation.
Pharmacology
Bryostatin has been found to have a wide range of biological activities, including anti-cancer, anti-viral, and neuroprotective effects. It is most well-known for its potent anti-cancer properties, which are believed to be due to its ability to modulate the activity of protein kinase C (PKC), a key regulator of cell growth and survival.
Clinical Use
Bryostatin has been investigated in numerous clinical trials for the treatment of various types of cancer, including melanoma, non-Hodgkin's lymphoma, and kidney cancer. It has also been studied for its potential use in the treatment of Alzheimer's disease and HIV.
Related Terms
- Macrolide
- Polyketide
- Protein kinase C
- Melanoma
- Non-Hodgkin's lymphoma
- Kidney cancer
- Alzheimer's disease
- HIV
See Also
External links
- Medical encyclopedia article on Bryostatin
- Wikipedia's article - Bryostatin
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