Calcifediol

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Calcifediol

Calcifediol (pronounced kal-si-FE-diol), also known as 25-hydroxyvitamin D (25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol).

Etymology

The term "Calcifediol" is derived from the Latin calcis (lime) and federe (to nourish), indicating its role in the absorption of dietary calcium.

Function

Calcifediol is converted in the kidneys by the enzyme 25-hydroxyvitamin D3 1-alpha-hydroxylase to calcitriol (1,25-dihydroxyvitamin D3), the active form of vitamin D. Calcitriol binds to the vitamin D receptor in target tissues and regulates the absorption of calcium and phosphate from the gut and reabsorption of calcium in the kidneys to maintain serum calcium levels.

Clinical significance

Measurement of serum 25(OH)D concentrations can provide a good index of circulating vitamin D activity in patients not suffering from renal disease. Deficiency of 25(OH)D is associated with bone diseases such as rickets in children and osteomalacia and osteoporosis in adults.

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