Cocaine

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Cocaine is a benzoid acid ester that that was originally used as a local anesthetic, but is no longer used because of its potent addictive qualities. When given in high doses systemically, cocaine has mood elevating effects that have led to its widescale abuse.

Liver safety of Cocaine

High doses of cocaine can be associated with toxic reactions including hyperthermia, rhabdomyolysis, shock and acute liver injury which can be severe and even fatal.

Mechanism of action of Cocaine

Cocaine (koe kane') is a potent local anesthetic that appears to act by inhibition of voltage-gated sodium channels, increasing the threshold for electric excitability of nerve axons and thus decreasing neuroconduction. In the central nervous system, cocaine appears to block both norepinephrine and serotonin reuptake. High doses produce euphoria followed by withdrawal symptoms, leading to a repeated desire to restart it and great abuse potential.

Side effects of Cocaine

Chronic use is associated with irritability, paranoia, violence and drug seeking behavior.

Addiction potential

Cocaine is one of the most addictive medications known. For this reason, cocaine is listed as a Schedule I drug, indicating that it has high abuse potential and no current medical usefulness. Cocaine abuse is relatively common; an estimated 600,000 Americans regularly abuse cocaine.


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