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Congenital hypoplastic anemia

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(kun-JEH-nih-tul HY-poh-PLAS-tik uh-NEE-mee-uh)A very rare disorder in which the bone marrow doesn’t make enough red blood cells. It is usually seen in the first year of life. Patients may have deformed thumbs and other physical problems. They also have an increased risk of leukemia and sarcoma, especially osteosarcoma (bone cancer). Patients with congenital hypoplastic anemia may have a mutation (change) in one of the genes that make proteins found in the cell’s ribosomes. Also called Blackfan–Diamond anemia, congenital pure red cell aplasia, DBA, Diamond-Blackfan anemia, erythrogenesis imperfecta, and inherited erythroblastopenia.

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