Delta-sleep-inducing peptide
Delta-sleep-inducing peptide
Delta-sleep-inducing peptide (DSIP), pronounced as /ˈdɛltə ˈsliːp ɪnˈdjuːsɪŋ ˈpeɪptʌɪd/, is a neuropeptide that induces sleep and modulates REM sleep. It was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep.
Etymology
The term "Delta-sleep-inducing peptide" is derived from its function. The word "Delta" refers to the type of brain waves that are most commonly associated with deep sleep. "Sleep-inducing" refers to the peptide's ability to induce sleep, and "peptide" is a type of compound consisting of two or more amino acids linked in a chain.
Function
DSIP has been found to have many roles in the body aside from sleep. It has been shown to have an effect on luteinizing hormone levels, corticotropin release, and the response to opioid peptides. It also exhibits a low molecular weight, which allows it to cross the blood-brain barrier.
Related Terms
- Neuropeptide: Any of a group of compounds that function as neurotransmitters and are formed from amino acids.
- Brain waves: Patterns of neuronal electrical activity generated by the brain.
- Luteinizing hormone: A hormone produced by gonadotropic cells in the anterior pituitary gland.
- Corticotropin: A peptide hormone that is produced by the anterior pituitary gland and stimulates the adrenal cortex.
- Opioid: Any compound that binds to opioid receptors in the brain and creates an analgesic effect.
- Blood-brain barrier: A highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system.
External links
- Medical encyclopedia article on Delta-sleep-inducing peptide
- Wikipedia's article - Delta-sleep-inducing peptide
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