Doxifluridine

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Doxifluridine

Doxifluridine (pronounced dox-i-flu-ri-dine) is a chemotherapeutic agent used in the treatment of certain types of cancer. It is a pyrimidine analog that inhibits DNA synthesis, thereby preventing the growth and proliferation of cancer cells.

Etymology

The term "Doxifluridine" is derived from the Greek words "doxi", meaning "worthy", and "fluridine", a term used in pharmacology to refer to a class of drugs that inhibit DNA synthesis.

Usage

Doxifluridine is primarily used in the treatment of gastrointestinal cancer, including stomach cancer and colorectal cancer. It may also be used in the treatment of other types of cancer, as determined by a healthcare provider.

Mechanism of Action

Doxifluridine works by inhibiting the synthesis of DNA in cancer cells. It is a prodrug, which means it is converted into its active form, 5-fluorouracil, in the body. This active form interferes with the enzyme thymidylate synthase, which is necessary for DNA replication and repair. By inhibiting this enzyme, Doxifluridine prevents cancer cells from replicating and growing.

Side Effects

Like all chemotherapeutic agents, Doxifluridine can cause side effects. These may include nausea, vomiting, diarrhea, and fatigue. More serious side effects may include bone marrow suppression, which can lead to a decrease in white blood cells, red blood cells, and platelets.

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