E-SCREEN
E-SCREEN
E-SCREEN (pronounced: eee-screen) is a scientific assay used in the field of toxicology to measure the estrogenic activity of chemicals. It was developed by Dr. Ana M. Soto and Dr. Carlos Sonnenschein at the Tufts University School of Medicine.
Etymology
The term "E-SCREEN" is an abbreviation of "Estrogen SCREENing". It was named for its primary function, which is to screen substances for estrogenic activity.
Description
The E-SCREEN assay is a cell proliferation assay that uses human breast cancer cells (MCF-7 cells) that are estrogen-responsive. The assay measures the ability of a substance to induce cell proliferation in these cells, which is an indicator of estrogenic activity. The E-SCREEN assay is used in environmental health research to identify potential endocrine disruptors.
Related Terms
- Estrogen: A group of hormones that play an important role in the normal sexual and reproductive development in women.
- Toxicology: The study of the adverse effects of chemical substances on living organisms.
- Endocrine disruptors: Chemicals that can interfere with endocrine (or hormone) systems.
- MCF-7 cells: A particular cell line that is used in cancer research. These cells are known to be responsive to estrogen.
See Also
External links
- Medical encyclopedia article on E-SCREEN
- Wikipedia's article - E-SCREEN
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