EP300

EP300

EP300 (pronounced E-P-three-hundred), also known as E1A binding protein p300, is a gene that encodes the p300 protein in humans. The p300 protein is a type of Histone acetyltransferase that regulates transcription via chromatin remodeling.

Etymology

The name EP300 is derived from its initial discovery as an E1A-associated protein with a molecular weight of 300 kDa. The E1A protein is a product of the Adenovirus E1A gene, which was found to bind with the p300 protein, hence the name.

Function

The EP300 protein is a Transcription coactivator that interacts with numerous transcription factors. It has histone acetyltransferase activity and acetylates both histone and non-histone proteins, playing a crucial role in regulating gene expression. Mutations in the EP300 gene are associated with a variety of diseases, including Rubinstein-Taybi syndrome and certain types of cancer.

Related Terms

• Histone acetyltransferase
• Transcription (genetics)
• Adenovirus
• Transcription coactivator
• Rubinstein-Taybi syndrome

See Also

• CREB-binding protein
• Transcription factor

External links

• Medical encyclopedia article on EP300
• Wikipedia's article - EP300

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