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Entecavir

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Information about Entecavir

Entecavir is a guanosine nucleoside analogue used in the treatment of chronic hepatitis B virus (HBV) infection.

Liver safety of Entecavir

Entecavir therapy can be associated with flares of the underlying hepatitis B during or after therapy, but has not been linked to cases of clinically apparent liver injury.

Mechanism of action of Entecavir

Entecavir (en tek' a vir) is a guanosine analogue with potent activity against HBV and minimal activity against HIV. Entecavir is phosphorylated intracellularly where it acts by competing with guanosine for uptake by the HBV DNA polymerase and incorporation into the growing HBV DNA molecule, leading to inhibition of polymerase activity and chain termination. Entecavir lowers HBV DNA levels and leads to improvements in serum aminotransferase levels in the majority of patients. Long term therapy is well tolerated and antiviral resistance to entecavir is rare.

FDA approval information for Entecavir

Entecavir was approved by the FDA in 2005 and is currently widely used.

Clinical use of Entecavir

Entecavir is indicated for the treatment of chronic hepatitis B and is available in 0.5 and 1 mg tablets under the brand name of Baraclude. An oral solution of 0.05 mg/mL is also available.

Dosage and administration for Entecavir

The recommended dose of entecavir is 0.5 mg orally once daily in adults (and children over the age of 16) with typical chronic hepatitis B and 1.0 mg once daily for patients with lamivudine-resistant HBV infection. Entecavir has slight antiviral activity against HIV which predisposes to antiviral resistance and should not be used alone in patients with HBV-HIV co-infection.

Side effects of Entecavir

Side effects from entecavir are infrequent.

Antiviral agents

Drugs for HIV Infection, in the Subclass Antiretroviral Agents

Drugs for Hepatitis B

Drugs for Hepatitis C

HCV NS5A Inhibitors

HCV NS5B (Polymerase) Inhibitors

HCV Protease Inhibitors

Combination Therapies

Drugs for Herpes Virus Infections (HSV, CMV, others)

Drugs for Influenza


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