Estrone (medication)
Estrone (medication)
Estrone (pronunciation: /ˈɛstrəʊn/), also known as E1 and oestrone, is a naturally occurring estrogen steroid hormone and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol.
Etymology
The term "estrone" is derived from the Greek oistros, meaning "gadfly" or "frenzy", and one, a suffix used in chemical nomenclature to denote a ketone.
Pharmacology
Estrone is synthesized from androstenedione, a steroid hormone produced in the adrenal glands and gonads. It is converted into estrone by the enzyme aromatase. Estrone can also be converted back into androstenedione.
Medical Uses
Estrone is used in hormone replacement therapy to treat symptoms of menopause in women. It is also used in the treatment of breast cancer and prostate cancer.
Side Effects
Common side effects of estrone include nausea, vomiting, breast tenderness, irregular menstrual periods, and weight changes. More serious side effects may include blood clots, stroke, and heart disease.
Related Terms
- Estrogen: A group of steroid hormones that promote the development and maintenance of female characteristics of the body.
- Estradiol: The most potent and prevalent endogenous estrogen sex hormone.
- Estriol: A minor endogenous estrogen sex hormone.
- Androstenedione: A steroid hormone that is a common precursor in the biochemical synthesis of estrone.
- Aromatase: An enzyme that synthesizes estrogen.
See Also
External links
- Medical encyclopedia article on Estrone (medication)
- Wikipedia's article - Estrone (medication)
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