Information about Griseofulvin
Griseofulvin is a fungistatic agent used to treat superficial fungal skin infections such as tinea capitis and pedis.
Liver safety of Griseofulvin
Griseofulvin therapy can cause transient mild-to-moderate serum aminotransferase elevations and has very rarely been linked to clinically apparent acute drug induced liver injury.
Mechanism of action of Griseofulvin
Griseofulvin (gris" ee oh ful' vin) is a metabolic product of Penicillium griseofulvum with potent activity against fungal agents. Its antifungal activity is believed to be due to disruption of the mitotic spindle of fungal cells, which interferes with cell division.
Griseofulvin may also inhibit fungal DNA replication. Griseofulvin has been used for superficial dermatophyte infections (tinea corporis, capitis, barbae, cruris, pedis or unguium) for many years.
Dosage and administration for Griseofulvin
Griseofulvin is available in generic forms as tablets of 500 mg, and an oral suspension in several generic forms and under the brand names of Grifulvin V and as film coated tablets of 125 and 250 mg as Gris-PEG. Because of the availability of other more potent antifungal agents with a wider sprectum of action, griseofulvin is now rarely used. The usual recommended dose is 500 to 1000 mg daily depending upon the type and severity of the infection. == Side effects of Griseofulvin == Common side effects include nausea, vomiting and headache.
The following drugs are antifungal agents:
- Amphotericin B
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