HPTN 052
HPTN 052
HPTN 052 (pronounced as H-P-T-N zero five two) is a landmark clinical trial in the field of HIV research. The trial was conducted by the HIV Prevention Trials Network (HPTN), a worldwide collaborative clinical trials network that develops and tests the safety and efficacy of primarily non-vaccine interventions designed to prevent the transmission of HIV.
Etymology
The term "HPTN 052" is an acronym derived from the name of the organization that conducted the trial, the HIV Prevention Trials Network (HPTN), and the number 052, which is the specific identifier for this trial.
Overview
HPTN 052 began in 2005 and was a randomized, controlled trial that enrolled 1,763 serodiscordant couples, in which one partner was HIV-positive and the other was HIV-negative. The trial was conducted in nine countries: Botswana, Brazil, India, Kenya, Malawi, South Africa, Thailand, the United States, and Zimbabwe.
The primary aim of HPTN 052 was to evaluate whether antiretroviral therapy (ART) could prevent the sexual transmission of HIV among serodiscordant couples. The trial found that early initiation of ART reduced HIV transmission by 96%, providing definitive evidence that treatment is an effective tool for HIV prevention.
Related Terms
- HIV: Human Immunodeficiency Virus, the virus that causes AIDS.
- Serodiscordant: A term used to describe a couple in which one partner is HIV-positive and the other is HIV-negative.
- Antiretroviral therapy (ART): Treatment for HIV infection that uses a combination of drugs to suppress the virus.
- HIV Prevention Trials Network (HPTN): A worldwide collaborative clinical trials network that develops and tests interventions designed to prevent the transmission of HIV.
External links
- Medical encyclopedia article on HPTN 052
- Wikipedia's article - HPTN 052
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