Haloperidol

From WikiMD

Haloperidol drug used to treat certain mental and neurological disorders. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of antiemetic and a type of antipsychotic. Also called Haldol.

Information about Haloperidol

Haloperidol is a conventional antipsychotic agent used in the treatment of acute and chronic psychosis.

Liver safety of Haloperidol

Haloperidol therapy is commonly associated with minor serum aminotransferase elevations and in very rare instances has been linked to clinically apparent acute liver injury.

Mechanism of action of Haloperidol

Haloperidol (hal" oh per' i dol) is a butyrophenone derivative which appears to act as a dopamine type 2 (D2) receptor antagonist, but has other central and peripheral effects. Haloperidol is indicated for the therapy of acute and chronic psychoses and for controlling tics and vocal utterances in Tourette syndrome. Haloperidol is also used for short-term treatment of severe behavior problems in children with hyperactivity.

FDA approval information for Haloperidol

Haloperidol was approved for use in the United States in 1967, but is currently infrequently used, having been replaced in large part by the atypical antipsychotics, which have fewer extrapyramidal side effects.

Dosage and administration for Haloperidol

Haloperidol is available as tablets of 0.5, 1, 2, 5, 10 and 20 mg, as an oral solution and in several formulations for parenteral use in generic forms and under the brand names Haldol and Peridol. The dose of haloperidol ranges considerably based upon patient age, severity of illness and concomitant medications. The typical range of maintenance doses in adults is 0.5 to 5 mg two to three times daily.

Side effects of Haloperidol

Common side effects include drowsiness, restlessness, dizziness, headache, blurred vision, tremor and weight gain. Rare, but potentially severe adverse events include cardiovascular events, QTc prolongation, tardive dyskinesia, neuroleptic malignant syndrome and embryo-fetal toxicity.

Antipsychotic agents

First Generation

Second Generation (Atypicals)


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