Homologene
Homologene
Homologene (pronounced: /hoʊˈmɒləˌdʒiːn/) is a system for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic genomes.
Etymology
The term "Homologene" is derived from the words "homolog" and "gene". "Homolog" comes from the Greek words "homos" meaning "same" and "logos" meaning "relation". "Gene" is derived from the Greek word "genos" meaning "birth" or "origin". Thus, Homologene essentially refers to genes that have the same relation or origin.
Definition
Homologene is a tool developed by the National Center for Biotechnology Information (NCBI) to aid in the identification of Orthologs and Paralogs. It groups together genes that are derived from a common ancestor and are present in different species (orthologs), or in the same species (paralogs).
Function
Homologene compares protein sequences from different organisms to identify homologous genes. It uses a combination of computational methods to detect sequence similarity and evolutionary relationships. The Homologene database includes information about gene names, descriptions, locations, and other annotations.
Related Terms
- Ortholog: A gene in different species that evolved from a common ancestral gene by speciation.
- Paralog: Genes related by duplication within a genome.
- Eukaryotic: An organism whose cells contain a nucleus and other structures (organelles) enclosed within membranes.
- National Center for Biotechnology Information (NCBI): Part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH).
External links
- Medical encyclopedia article on Homologene
- Wikipedia's article - Homologene
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