IKK2
IKK2
IKK2 (pronounced "eye-kay-kay-two"), also known as Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta or IκB kinase beta, is a protein that in humans is encoded by the IKBKB gene.
Pronunciation
The pronunciation of IKK2 is "eye-kay-kay-two".
Etymology
The term IKK2 is an abbreviation derived from the full name of the protein, "Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta". The "IKK" stands for "IκB kinase", and the "2" denotes that it is the second subtype of this protein.
Function
IKK2 is part of the IKK complex, which is involved in the activation of NF-κB, a transcription factor that plays a crucial role in immune and inflammatory responses. The IKK complex consists of two catalytic subunits, IKK1 and IKK2, and a regulatory subunit, NEMO (NF-κB essential modulator). IKK2 phosphorylates the inhibitor of NF-κB, leading to its degradation and the subsequent activation of NF-κB.
Related Terms
- IKK1: The other catalytic subunit of the IKK complex.
- NEMO: The regulatory subunit of the IKK complex.
- NF-κB: A transcription factor activated by the IKK complex.
- IκB: The inhibitor of NF-κB, which is phosphorylated and degraded by IKK2.
See Also
External links
- Medical encyclopedia article on IKK2
- Wikipedia's article - IKK2
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