ISRIB
ISRIB
ISRIB (pronounced "eye-srib"), also known as Integrated Stress Response Inhibitor is a small molecule that inhibits the Integrated Stress Response (ISR). The ISR is a cellular response to various stress conditions, such as viral infection, nutrient deprivation, and accumulation of misfolded proteins.
Pronunciation
- IPA: /aɪsɹɪb/
Etymology
The term ISRIB is an acronym derived from Integrated Stress Response Inhibitor.
Function
ISRIB inhibits the eIF2α phosphorylation-mediated downregulation of protein synthesis, a key component of the ISR. This inhibition allows for the continued synthesis of proteins even under stress conditions. ISRIB has been shown to enhance memory and learning in mice, and it has potential therapeutic applications in neurodegenerative diseases and cognitive disorders.
Related Terms
- Integrated Stress Response: A cellular response to various stress conditions.
- eIF2α: A protein that plays a crucial role in the ISR.
- Phosphorylation: A process that modifies proteins by adding a phosphate group.
- Protein Synthesis: The process by which cells make proteins.
- Neurodegenerative Diseases: Diseases characterized by the progressive loss of structure or function of neurons.
- Cognitive Disorders: Disorders that significantly affect cognitive abilities including learning, memory, perception, and problem solving.
External links
- Medical encyclopedia article on ISRIB
- Wikipedia's article - ISRIB
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