Isolated primary immunoglobulin M deficiency
Isolated Primary Immunoglobulin M Deficiency
Isolated Primary Immunoglobulin M Deficiency (IPIMD), pronounced as /ˌaɪsəˈleɪtɪd ˈpraɪməri ˌɪmjʊnəʊɡləˈbjuːlɪn ɛm dɪˈfɪʃənsi/, is a rare immunodeficiency disorder characterized by decreased levels of Immunoglobulin M (IgM) in the blood, while the levels of other immunoglobulins such as Immunoglobulin G (IgG) and Immunoglobulin A (IgA) remain normal.
The term originates from the following words: 'Isolated' (from Latin 'insulatus' meaning 'made into an island'), 'Primary' (from Latin 'primarius' meaning 'of the first rank'), 'Immunoglobulin' (from Latin 'immunis' meaning 'exempt' and 'globulus' meaning 'small sphere'), and 'Deficiency' (from Latin 'deficientia' meaning 'a lacking').
Symptoms
Patients with IPIMD often present with recurrent bacterial infections, especially of the respiratory tract. Other symptoms may include chronic diarrhea, sinusitis, and otitis media.
Diagnosis
Diagnosis of IPIMD is based on the detection of low serum IgM levels in the presence of normal levels of other immunoglobulins. This is usually done through a blood test.
Treatment
Treatment for IPIMD is primarily supportive and includes antibiotic therapy for bacterial infections and immunoglobulin therapy for those with severe infections.
See Also
- Immunodeficiency
- Immunoglobulin M
- Immunoglobulin G
- Immunoglobulin A
- Antibiotic therapy
- Immunoglobulin therapy
References
External Links
External links
- Medical encyclopedia article on Isolated primary immunoglobulin M deficiency
- Wikipedia's article - Isolated primary immunoglobulin M deficiency
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