Isosorbide mononitrate

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Information about Isosorbide mononitrate

Isosorbide mononitrate (eye" soe sor' bide mon" oh nye' trate) is a prodrug of nitric oxide used to prevent (but not to treat) attacks of angina pectoris. Isosorbide mononitrate is well absorbed orally but, unlike nitroglycerin, does not undergo first pass metabolism by the liver and can be given in typical oral forms.

FDA approval information for Isosorbide mononitrate

Isosorbide mononitrate was approved for use in the United States in 1991 for prophylaxis of angina.

Dosage and administration for Isosorbide mononitrate

It is available in generically and under the brand name ISMO and Monoket in tablets of 10 and 20 mg. The recommended dose regimen is 20 mg twice daily given 7 hours apart (thus with a 10 hour rest period to avoid nitrate tolerance). Isosorbide mononitrate is also available in extended release forms generically and under the brand name Imdur in 30, 60 and 120 mg tablets, the recommended initial dose being 30 to 60 mg once daily, gradually increasing to a maximum of 240 once daily.

Side effects of Isosorbide mononitrate

Side effects of isosorbide dinitrate include headache, dizziness, weakness, nausea and vomiting, peripheral edema, flushing, syncope, tachycardia, palpitations and postural hypotension.


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