Kimura's disease
Kimura's Disease
Kimura's disease (pronounced: kee-moo-rahz disease) is a rare, chronic inflammatory disorder of unknown etiology. It was first described by Kimm and Szeto in 1937, but it was not until 1948 that Kimura et al. recognized it as a separate disease entity, hence the name Kimura's disease.
Etymology
The disease is named after T. Kimura, a Japanese dermatologist who, along with his colleagues, first described the condition in detail in 1948. The term "disease" is derived from the Old French desaise, meaning lack of ease, discomfort, or illness.
Definition
Kimura's disease is characterized by painless subcutaneous nodules, predominantly in the head and neck region, often associated with regional lymphadenopathy and/or salivary gland involvement. The disease is more common in Asian males and usually presents in the second or third decade of life.
Symptoms
The most common symptoms of Kimura's disease include:
- Painless, slowly growing lymph node swelling, usually in the neck
- Eosinophilia (an abnormal increase in the number of eosinophils in the blood)
- Increased serum Immunoglobulin E (IgE) levels
- Possible involvement of other organs, such as the kidneys
Diagnosis
Diagnosis of Kimura's disease is typically based on clinical findings, blood tests showing eosinophilia and elevated IgE levels, and histopathological examination of the affected tissue. The disease must be differentiated from other conditions that can cause similar symptoms, such as Angiolymphoid Hyperplasia with Eosinophilia (ALHE), Lymphoma, and Parasitic Infections.
Treatment
Treatment options for Kimura's disease include surgical removal of the affected lymph nodes, corticosteroid therapy, and radiation therapy. However, the disease often recurs after treatment.
Prognosis
The prognosis for Kimura's disease is generally good, although the disease can cause significant morbidity due to its chronic, relapsing nature and potential for organ involvement.
See Also
- Eosinophilia
- Immunoglobulin E
- Lymphadenopathy
- Angiolymphoid Hyperplasia with Eosinophilia
- Lymphoma
- Parasitic Infections
External links
- Medical encyclopedia article on Kimura's disease
- Wikipedia's article - Kimura's disease
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