Linear epitope
Linear Epitope
A Linear Epitope (pronounced: /ˈlɪn.i.ər ˈɛpɪˌtoʊp/), also known as continuous epitope, is a type of Epitope that is recognized by the Antibodies in its linear, sequential form. The term is derived from the Greek words 'epi' meaning 'upon' and 'topos' meaning 'place', indicating the site on an Antigen to which an antibody binds.
Definition
A Linear Epitope is defined as a sequence of consecutive Amino Acids in the primary structure of an antigen that is recognized by the immune system. Unlike Conformational Epitopes, which are formed by spatially distinct amino acids brought together by the folding of the protein, Linear Epitopes are recognized by antibodies in their linear, unfolded state.
Recognition by Antibodies
The recognition of Linear Epitopes by antibodies is a crucial aspect of the immune response. The B Cells of the immune system produce antibodies that specifically bind to the Linear Epitopes on the surface of antigens, marking them for destruction or neutralization.
Related Terms
- Epitope: The specific portion of an antigen to which an antibody binds.
- Antibodies: Proteins produced by the immune system that bind to specific antigens.
- Antigen: A substance that induces an immune response, especially the production of antibodies.
- Amino Acids: The building blocks of proteins.
- B Cells: A type of white blood cell that produces antibodies.
- Conformational Epitope: A type of epitope that is recognized by antibodies in its folded, three-dimensional form.
See Also
External links
- Medical encyclopedia article on Linear epitope
- Wikipedia's article - Linear epitope
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