Lorazepam

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Information about Lorazepam

Lorazepam is an orally available benzodiazepine used widely in the therapy of anxiety and insomnia

Liver safety of Lorazepam

As with most benzodiazepines, lorazepam therapy has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from lorazepam has not been reported and must be very rare, if it occurs at all.

Mechanism of action of Lorazepam

Lorazepam (lor az' e pam) is a benzodiazepine that is widely used in the therapy of anxiety.  Lorazepam is also used in parenteral form for therapy of status epilepticus and in preoperative sedation and management of nausea and vomiting.  The antianxiety (anxiolytic) and soporific activity of the benzodiazepines is mediated by their ability to enhance gamma-aminobutyric acid (GABA) mediated inhibition of synaptic transmission through binding to the GABA A receptor. 

FDA approval information for Lorazepam

Lorazepam was approved in the United States in 1977, and currently more than 20 million prescriptions are filled yearly.  Indications include management of anxiety disorders and short term relief of symptoms of anxiety

Dosage and administration for Lorazepam

Lorazepam is available in tablets of 0.5, 1 and 2 mg in several generic forms and under the brand name Ativan.  Parenteral formulations of lorazepam (2 and 4 mg per mL) are available for use in status epilepticus and for preoperative sedation and control of nausea and vomiting after cancer chemotherapy.  The recommended oral dose for adults is 0.5 to 1 mg two to three times daily, increasing as needed to a maximum dose of 10 mg daily in divided doses. 

Side effects of Lorazepam

The most common side effects of lorazepam are dose related and include drowsiness, lethargy, ataxia, dysarthria and dizziness.  Tolerance develops to these side effects, but tolerance may also develop to the effects on anxiety and insomnia.

Benzodiazipines

Anticonvulsants Drugs

Drug class for Lorazepam

Anticonvulsants, and Benzodiazepines]

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