MSin3 interaction domain

The MSin3 interaction domain (pronounced: M Sin Three Interaction Domain) is a specific region within a protein that facilitates interaction with the MSin3 protein. This domain is crucial for the regulation of gene expression and is often found in transcriptional repressors.

Etymology

The term "MSin3 interaction domain" is derived from the protein with which it interacts, the MSin3 protein. The "M" and "Sin" in MSin3 stand for "Mammalian" and "Switch-Insensitive", respectively, referring to the protein's discovery in mammalian cells and its insensitivity to the switch between active and repressed states of gene expression.

Function

The MSin3 protein is a transcriptional repressor, meaning it inhibits the process of transcription, which is the first step in gene expression. The MSin3 interaction domain is a specific region within other proteins that allows them to interact with the MSin3 protein. This interaction is crucial for the regulation of gene expression, as it allows the MSin3 protein to inhibit transcription when necessary.

Related Terms

Transcription (genetics): The process by which the information in a strand of DNA is copied into a new molecule of messenger RNA (mRNA).
Gene expression: The process by which the genetic code - the nucleotide sequence - of a gene is used to direct protein synthesis and produce the structures of the cell.
Protein-protein interaction: The specific physical contacts between proteins that occur during many critical cellular processes.
Transcriptional repressor: A protein that suppresses the process of transcription.

External links

Medical encyclopedia article on MSin3 interaction domain
Wikipedia's article - MSin3 interaction domain

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MSin3 interaction domain